What is the Difference Between
Mesotherapy, Skin Boosters,
Exosomes & Polynucleotides?

Mesotherapy is the original injectable skin treatment, developed in France by Dr Michel Pistor in 1952. It involves administering a customised cocktail of active ingredients — vitamins, minerals, amino acids, hyaluronic acid, peptides, and other active compounds — via micro-injections into the mesoderm (the middle layer of skin).

Unlike the other three treatments, which use a single primary active agent, mesotherapy is defined by its cocktail approach: the practitioner selects and combines multiple ingredients based on the individual patient’s specific concern. This makes it the most versatile of all four treatments, capable of addressing skin quality, hair restoration, cellulite, and pain management in a single modality.

Skin Boosters are a specific category of injectable treatment using stabilised, non-cross-linked hyaluronic acid (HA) formulated specifically for deep skin hydration. Unlike dermal fillers — which use cross-linked HA to add structural volume — Skin Boosters use a softer, more fluid HA that integrates into the dermis and acts as a water-binding reservoir.

The primary goal is skin quality improvement from within: restoring deep hydration, improving skin elasticity, and creating the luminous “glow from within” effect that is often the first thing patients and observers notice. Results are both immediate (hydration) and cumulative (collagen stimulation develops over weeks).

Exosomes represent the most recent frontier in regenerative aesthetics. They are extracellular vesicles — tiny membrane-bound particles naturally released by cells — that carry biological messages between cells in the form of proteins, lipids, RNA and growth factors. In aesthetic medicine, exosomes derived from stem cells are used to trigger the skin’s own regenerative processes at a molecular level.

Unlike the previous two treatments, which deliver actives directly, exosomes work by signalling to existing cells to change their behaviour: stimulating fibroblasts to produce more collagen, promoting anti-inflammatory responses, and accelerating tissue repair. This makes them particularly powerful in post-procedure recovery protocols and for patients with advanced skin ageing or photoageing.

Polynucleotides (PN) — also known as PDRN (polydeoxyribonucleotide) — are fragments of DNA derived from salmon or trout sperm, purified and processed for clinical use. They work by stimulating tissue repair at a DNA level: binding to adenosine receptors on cells to promote cell proliferation, increase collagen and elastin production, reduce inflammation, and improve blood supply to the treated area.

Their mechanism is distinct from all three other treatments: polynucleotides essentially rebuild the scaffolding of the skin from the ground up by creating the biological conditions for new tissue to form. This makes them the treatment of choice for skin laxity, tissue repair after damage (sun, scarring, ageing), and long-term structural improvement.